The microbiological stability of cosmetic products is crucial, especially in products with high water content, such as creams. Therefore, preservatives are used in order to protect consumers from harmful pathogens that would otherwise invade the cosmetics. Despite their function, the addition of preservatives can be considered controversial in the ...

By Tatjana Stević, Nemanja Krgovic, Jelena Mudrić, Nada Cujic Nikolic, Ana Žugić, Dubravka Bigović, Tea Ganić, Katarina Šavikin

Comparison between conventional and microwave-assisted hydrodistillation at different power levels has been applied for the extraction of essential oil from Zingiber officinale Rosc. rhizome. In addition to the collected essential oils, as the main products, hydrolats were also collected, as valuable by-products from both extraction techniques. A c...

By Zorica Drinić, Miloš Jovanović, Dejan Pljevljakušić, Nada Čujić-Nikolić, Dubravka Bigović, Katarina Šavikin

Willowherb (Epilobium angustifolium L.) leaves are a valuable source of polyphenolic compounds (phenolic acids, flavonoids, and ellagitannins) that are mainly used in the treatment of benign prostatic hyperplasia. In the presented study, the impacts of maltodextrin and whey protein as carriers on the efficiency of spray drying and physicochemical p...

By Miloš Janković, Zorica Drinić, Dubravka Bigović, Gordana Zdunić, Jelena Mudrić, Katarina Šavikin

The roots of yellow gentian, Gentiana lutea L. (Gentianaceae) are used in traditional medicine for the treatment of gastrointestinal disorders, with the literature data indicate a local gastric effect of gentian root extract (GRE) and support the use of the solid pharmaceutical forms. Gentiopicroside, as a dominant secoiridoid in the GRE, has a sho...

By Jelena Mudrić, Mirjana Pajić, Dubravka Bigović, Jelena Đuriš

This study aimed to assess the antineurodegenerative and antioxidant activity of Helichrysum plicatum flower extract, as well as to identify extract ingredients with acceptable pharmacokinetic parameters such as gastrointestinal absorption, blood-brain barrier permeation, and P-glycoprotein-mediated effusion for optimal therapeutic brain exposure. ...

By Miloš Jovanović, Zorica Drinić, Dubravka Bigović, Ana Alimpić-Aradski, Sonja Duletić-Laušević, Katarina Šavikin

Tanacetum parthenium (L.) Schulz Bip., Asteraceae (feverfew), being a medicinal plant with a long tradition in European folk medicine, has been used to treat headache, fever, rheumatism, asthma, stomach pains, and other conditions related to inflammation. Although feverfew is often used for migraine headaches, numerous literature data stated the in...

By Vladan Tadić, Jelena Živković, Dubravka Bigović, Ana Žugić

The stability of linseed (Linum usitatissimum) oil has been investigated through the exposition of two different samples, linseed oil without antioxidant and linseed oil with roesemary (Rosmarinus officinalis) extract, to ambient temperature conditions (25 °C) and refrigerator temperature conditions (4 °C). The oxidation degree of linseed oi...

By Zorica Drinić, Jelena Mudrić, Gordana Zdunić, Dubravka Bigović, Katarina Šavikin

Due to its high content of phenolics, black chokeberry has been proposed as a health-promoting material, especially use of chokeberry extract as a food or pharmaceuticals. Chokeberry extract was spray-dried using gum Arabic as a carrier. The optimal conditions for the efficient microencapsulation of chokeberry extract using spray-drying technique h...

By Nada Čujić-Nikolić, Nemanja Stanisavljević, Katarina Šavikin, Ana Kalaušević, Viktor Nedović, Dubravka Bigović, Teodora Janković

Biological activities of Sorbus aucuparia L. leaves extract was tested in our study. Antineurodegenerative activity was evaluated by acetylcholinesterase (AChE) and tyrosinase (TYR) inhibitory activity assays while antioxidant activity was by tested using four different assays. In all antioxidant test we noticed concentration dependent activity of ...

By Katarina Šavikin, Gordan Zdunić, Ana Alimpić, Dubravka Bigović, Dejan Pljevljakušić, Sonja Duletić-Laušević

Medicinal plant extracts have a broad antimicrobial activity, including antiviral effects. In our study, eleven dry extracts of ten different medicinal plants prepared with two solvents (5%, dimethyl sulfoxide (DMSO) and 30% ethanol in 5% DMSO) in different concentrations have been examined for anti-norovirus activity. The reduction of norovirus &g...

By Ivana Živković, Katarina Šavikin, Gordana Zdunić, Jelena Živković, Dubravka Bigović, Nebojša Menković, Dragoslav Radin