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Research Article

Biological activities of Sorbus aucuparia L. leaves extract

By
Katarina Šavikin ,
Katarina Šavikin
Contact Katarina Šavikin

Institute for Medicinal Plant Research “Dr. Josif Pančić”, Belgrade, Serbia

Gordan Zdunić ,
Gordan Zdunić

Institute for Medicinal Plant Research “Dr. Josif Pančić”, Belgrade, Serbia

Ana Alimpić ,
Ana Alimpić

Institute of Botany and Botanical Garden “Jevremovac”, Faculty of Biology, University of Belgrade, Belgrade, Serbia

Dubravka Bigović ,
Dubravka Bigović

Institute for Medicinal Plant Research "Dr. Josif Pančić", Belgrade, Serbia

Dejan Pljevljakušić ,
Dejan Pljevljakušić

Institute for Medicinal Plant Research "Dr. Josif Pančić", Belgrade, Serbia

Sonja Duletić-Laušević
Sonja Duletić-Laušević

Institute of Botany and Botanical Garden"Jevremovac", Faculty of Biology, University of Belgrade, Belgrade, Serbia

Abstract

Biological activities of Sorbus aucuparia L. leaves extract was tested in our study. Antineurodegenerative activity was evaluated by acetylcholinesterase (AChE) and tyrosinase (TYR) inhibitory activity assays while antioxidant activity was by tested using four different assays. In all antioxidant test we noticed concentration dependent activity of tested extract and the highest applied concentration of 500 μg/ml was the most active. Extract applied in concentration of 200 μg/ml showed higher percent of inhibition in DPPH test compared to both applied concentrations of standard substances BHA and BHT (50 and 100 μg/ml). In ABTS test, activity of extract applied in 500 μg/ml was comparable or higher then BHA and BHT/Vitamin C, respectively. Moreover, all concentrations of tested extract were significantly more active in ß-carotene test than vitamin C. The lowest concentration of extract (100 μg/ml) was the most active in TYR assay reaching 42.57 % of the inhibition while in AChE assay there was not statistically significant differences among all applied concentrations.


 

References

[{"id":2361,"citationNumber":"1.","type":"article-journal","title":"Cholinesterase inhibitors from botanicals","DOI":null,"author":[{"given":"F.","family":"Ahmed"},{"given":"R.M.","family":"Ghalib"},{"given":"P.","family":"Sasikala"},{"given":"K.K.","family":"Ahmed"}],"issued":{"date-parts":["2013"]},"container-title":"Pharmacognosy Reviews","volume":"7","issue":"14","page":"121"}]

[{"id":2362,"citationNumber":"2.","type":"article-journal","title":"Antioxidant Determinations by the Use of a Stable Free Radical","DOI":null,"author":[{"given":"M.S.","family":"Blois"}],"issued":{"date-parts":["1958"]},"container-title":"Nature","volume":"181","issue":null,"page":"1199\u20131200"}]

[{"id":2363,"citationNumber":"3.","type":"article-journal","title":"Optimization of chokeberry ( \u0301 Aronia melanocarpa (Michx.) Elliott) extraction, microencapsulation of extract by electrostatic extrusion and spray drying methods","DOI":null,"author":[{"given":"N.","family":"Cuji\u0107"}],"issued":{"date-parts":["2017"]},"container-title":"Lekovite Sirovine","volume":"37","issue":"0","page":"59\u201363"}]

[{"id":2364,"citationNumber":"4.","type":"article-journal","title":"Antioxidant activity of extracts obtained by different isolation procedures from some aromatic herbs grown in Lithuania","DOI":null,"author":[{"given":"A.","family":"Dapkevicius"},{"given":"R.","family":"Venskutonis"},{"given":"T.A.","family":"Beek"},{"given":"J.P.H.","family":"Linssen"}],"issued":{"date-parts":["1998"]},"container-title":"Journal of the Science of Food and Agriculture","volume":"77","issue":"1","page":"140\u2013146"}]

[{"id":2365,"citationNumber":"5.","type":"article-journal","title":"Biological activities of selected polyphenol-rich fruits related to immunity and gastrointestinal health","DOI":null,"author":[{"given":"P.","family":"Denev"},{"given":"M.","family":"Kratchanova"},{"given":"M.","family":"Ciz"},{"given":"A.","family":"Lojek"},{"given":"O.","family":"Vasicek"},{"given":"P.","family":"Nedelcheva"},{"given":"D.","family":"Blazheva"},{"given":"R.","family":"Toshkova"},{"given":"E.","family":"Gardeva"}],"issued":{"date-parts":["2014"]},"container-title":"Food Chemistry","volume":"157","issue":null,"page":"37-44"}]

[{"id":2366,"citationNumber":"6.","type":"article-journal","title":"Biological activities of selected polyphenol-rich fruits related to immunity and gastrointestinal health","DOI":null,"author":[{"given":"L.","family":"Yossifova"},{"given":"P.","family":"Hyrsl"},{"given":"L.","family":"Vojtek"}],"issued":{"date-parts":["2014"]},"container-title":"Food Chemistry","volume":"157","issue":null,"page":"37\u201344"}]

[{"id":2367,"citationNumber":"7.","type":"article-journal","title":"Insight into anticholinesterase and antioxidant potential of thirty-four Rosaceae samples and phenolic characterization of the active extracts by HPLC","DOI":null,"author":[{"given":"H.N.","family":"Ekin"},{"given":"A.","family":"Gokbulut"},{"given":"Z.U.","family":"Aydin"},{"given":"A.A.","family":"Donmez"},{"given":"I.E.","family":"Orhan"}],"issued":{"date-parts":["2016"]},"container-title":"Industrial Crops and Products","volume":"91","issue":null,"page":"104\u2013113"}]

[{"id":2368,"citationNumber":"8.","type":"article-journal","title":"A new and rapid colorimetric determination of acetylcholinesterase activity","DOI":null,"author":[{"given":"G.L.","family":"Ellman"},{"given":"K.","family":"Courtney"},{"given":"V.","family":"Andres"},{"given":"R.M.","family":"Featherstone"}],"issued":{"date-parts":["1961"]},"container-title":"Biochemical Pharmacology","volume":"7","issue":"2","page":"88\u201395"}]

[{"id":2369,"citationNumber":"9.","type":"article-journal","title":"Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson\u2019s disease","DOI":null,"author":[{"given":"E.","family":"Greggio"},{"given":"E.","family":"Bergantino"},{"given":"D.","family":"Carter"},{"given":"R.","family":"Ahmad"},{"given":"G.-E.","family":"Costin"},{"given":"V.J.","family":"Hearing"},{"given":"J.","family":"Clarimon"},{"given":"A.","family":"Singleton"},{"given":"J.","family":"Eerola"},{"given":"O.","family":"Hellstrom"},{"given":"P.J.","family":"Tienari"},{"given":"D.W.","family":"Miller"},{"given":"A.","family":"Beilina"},{"given":"L.","family":"Bubacco"},{"given":"M.R.","family":"Cookson"}],"issued":{"date-parts":["2005"]},"container-title":"Journal of Neurochemistry","volume":"93","issue":"1","page":"246\u2013 256"}]

[{"id":2370,"citationNumber":"10.","type":"article-journal","title":"The Content of Biologically Active Compounds in Some Fruits from Natural State","DOI":null,"author":[{"given":"E.","family":"Hallmann"},{"given":"E.","family":"Orpel"},{"given":"E.","family":"Rembia\u0142kowska"}],"issued":{"date-parts":["2011"]},"container-title":"Vegetable Crops Research Bulletin","volume":"75","issue":"1","page":"81\u2013 90"}]

[{"id":2371,"citationNumber":"11.","type":"article-journal","title":"Antioxidant and antiacetylcholinesterase activities of Sorbus torminalis (L.) Crantz (wild service tree) fruits","DOI":null,"author":[{"given":"G.","family":"Hasbal"},{"given":"T.","family":"Yilmaz-Ozden"},{"given":"A.","family":"Can"}],"issued":{"date-parts":["2015"]},"container-title":"Journal of Food and Drug Analysis","volume":"23","issue":"1","page":"57\u201362"}]

[{"id":2372,"citationNumber":"12.","type":"article-journal","title":"Antioxidant Capacity and Phenolic Content of Sweet Rowanberries","DOI":null,"author":[{"given":"A.T.","family":"Hukkanen"},{"given":"S.S.","family":"P\u00f6l\u00f6nen"},{"given":"S.O.","family":"K\u00e4renlampi"},{"given":"H.I.","family":"Kokko"}],"issued":{"date-parts":["2006"]},"container-title":"Journal of Agricultural and Food Chemistry","volume":"54","issue":"1","page":"112\u2013119"}]

[{"id":2373,"citationNumber":"13.","type":"article-journal","title":"Rowanberry Phenolics: Compositional Analysis and Bioactivities","DOI":null,"author":[{"given":"P.","family":"Kylli"},{"given":"L.","family":"Nohynek"},{"given":"R.","family":"Puupponen-Pimi\u00e4"},{"given":"B.","family":"WesterlundWikstr\u00f6m"},{"given":"G.","family":"McDougall"},{"given":"D.","family":"Stewart"},{"given":"M.","family":"Heinonen"}],"issued":{"date-parts":["2010"]},"container-title":"Journal of Agricultural and Food Chemistry","volume":"58","issue":"22","page":"11985\u201311992"}]

[{"id":2374,"citationNumber":"14.","type":"article-journal","title":"Screening for Tyrosinase Inhibitors among Extracts of Seashore Plants and Identification of Potent Inhibitors from Garcinia subelliptica","DOI":null,"author":[{"given":"T.","family":"Masuda"},{"given":"D.","family":"Yamashita"},{"given":"Y.","family":"Takeda"},{"given":"S.","family":"Yonemori"}],"issued":{"date-parts":["2005"]},"container-title":"Bioscience, Biotechnology, and Biochemistry","volume":"69","issue":"1","page":"197\u2013201"}]

[{"id":2375,"citationNumber":"15.","type":"article-journal","title":"Sorbus domestica L. leaf extracts as functional products: phytochemical profiling, cellular safety, pro-inflammatory enzymes inhibition and protective effects against oxidative stress in vitro","DOI":null,"author":[{"given":"M.","family":"Matczak"},{"given":"A.","family":"Marchelak"},{"given":"P.","family":"Michel"},{"given":"A.","family":"Owczarek"},{"given":"A.","family":"Piszczan"},{"given":"J.","family":"Kolodziejczyk-Czepas"},{"given":"P.","family":"Nowak"},{"given":"M.A.","family":"Olszewska"}],"issued":{"date-parts":["2018"]},"container-title":"Journal of Functional Foods","volume":"40","issue":null,"page":"207\u2013218"}]

[{"id":2376,"citationNumber":"16.","type":"article-journal","title":"A Novel Method for Measuring Antioxidant Capacity and its Application to Monitoring the Antioxidant Status in Premature Neonates","DOI":null,"author":[{"given":"N.J.","family":"Miller"},{"given":"C.","family":"Rice-Evans"},{"given":"M.J.","family":"Davies"},{"given":"V.","family":"Gopinathan"},{"given":"A.","family":"Milner"}],"issued":{"date-parts":["1993"]},"container-title":"Clinical Science","volume":"84","issue":"4","page":"407\u2013412"}]

[{"id":2377,"citationNumber":"17.","type":"article-journal","title":"Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-\u03b2 Peptide in Mice","DOI":null,"author":[{"given":"M.C.","family":"Morzelle"},{"given":"J.M.","family":"Salgado"},{"given":"M.","family":"Telles"},{"given":"D.","family":"Mourelle"},{"given":"P.","family":"Bachiega"},{"given":"H.S.","family":"Buck"},{"given":"T.A.","family":"Viel"}],"issued":{"date-parts":["2016"]},"container-title":"PLOS ONE","volume":"11","issue":"11","page":null}]

[{"id":2378,"citationNumber":"18.","type":"article-journal","title":"Antioxidant activity of inflorescences, leaves and fruits of three Sorbus species in relation to their polyphenolic composition","DOI":null,"author":[{"given":"M.A.","family":"Olszewska"},{"given":"P.","family":"Michel"}],"issued":{"date-parts":["2009"]},"container-title":"Natural Product Research","volume":"23","issue":"16","page":"1507\u20131521"}]

[{"id":2379,"citationNumber":"19.","type":"article-journal","title":"Assessment of the Content of Phenolics and Antioxidant Action of Inflorescences and Leaves of Selected Species from the Genus Sorbus Sensu Stricto","DOI":null,"author":[{"given":"M.A.","family":"Olszewska"},{"given":"S.","family":"Nowak"},{"given":"P.","family":"Michel"},{"given":"P.","family":"Banaszczak"},{"given":"A.","family":"Kicel"}],"issued":{"date-parts":["2010"]},"container-title":"Molecules","volume":"15","issue":"12","page":"8769\u20138783"}]

[{"id":2380,"citationNumber":"20.","type":"article-journal","title":"Profiling of Phenolic Compounds and Antioxidant Activity of Dry Extracts from the Selected Sorbus Species","DOI":null,"author":[{"given":"M.A.","family":"Olszewska"},{"given":"A.","family":"Presler"},{"given":"P.","family":"Michel"}],"issued":{"date-parts":["2012"]},"container-title":"Molecules","volume":"17","issue":"3","page":"3093\u20133113"}]

[{"id":2381,"citationNumber":"21.","type":"article-journal","title":"Comparison of the flavonoid aglycone contents of Apis mellifera propolis from various regions of Brazil","DOI":null,"author":[{"given":"Y.K.","family":"Park"},{"given":"M.H.","family":"Koo"},{"given":"M.","family":"Ikegaki"},{"given":"J.l","family":"Contado"}],"issued":{"date-parts":["1997"]},"container-title":"Arquivos de biologia e tecnologia","volume":"40","issue":"1","page":"97\u2013106"}]

[{"id":2382,"citationNumber":"22.","type":"article-journal","title":"Phytochemical and antioxidant profiles of leaves from different Sorbus L","DOI":null,"author":[{"given":"L.","family":"Raudone"},{"given":"R.","family":"Raudonis"},{"given":"K.","family":"Gaivelyte"},{"given":"A.","family":"Pukalskas"},{"given":"P.","family":"Vi\u0161kelis"},{"given":"P.R.","family":"Venskutonis"},{"given":"V.","family":"Janulis"}],"issued":{"date-parts":["2015"]},"container-title":"species, Natural Product Research","volume":"29","issue":"3","page":"281\u2013285"}]

[{"id":2383,"citationNumber":"23.","type":"article-journal","title":"Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents","DOI":null,"author":[{"given":"V.L.","family":"Singleton"},{"given":"J.A.","family":"Rossi"}],"issued":{"date-parts":["1965"]},"container-title":"American Journal of Enology and Viticulture","volume":"16","issue":"3","page":"144\u2013158"}]

[{"id":2384,"citationNumber":"24.","type":"article-journal","title":"Antioxidant and antineurodegenerative properties of st","DOI":null,"author":[{"given":"K.","family":"\u0160avikin"},{"given":"A.","family":"Alimpi\u0107"},{"given":"G.","family":"Zduni\u0107"},{"given":"J.","family":"\u017divkovi\u0107"},{"given":"T.","family":"Jankovi\u0107"},{"given":"N.","family":"Menkovi\u0107"},{"given":"L.","family":"Duleti\u0107"}],"issued":{"date-parts":["2017"]},"container-title":"John\u2019s-wort dry extract, Lekovite sirovine","volume":"37","issue":null,"page":"5\u20139"}]

[{"id":2385,"citationNumber":"25.","type":"article-journal","title":"Sorbus aucuparia and Sorbus aria as a Source of Antioxidant Phenolics, Tocopherols, and Pigments","DOI":null,"author":[{"given":"K.P.","family":"\u0160avikin"},{"given":"G.M.","family":"Zduni\u0107"},{"given":"D.B.","family":"Krsti\u0107-Milo\u0161evi\u0107"},{"given":"H.J.","family":"\u0160ircelj"},{"given":"D.D.","family":"Ste\u0161evi\u0107"},{"given":"D.S.","family":"Pljevljaku\u0161i\u0107"}],"issued":{"date-parts":["2017"]},"container-title":"Chemistry & Biodiversity","volume":"14","issue":"12","page":"1700329"}]

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