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Pregledni rad – Review Paper

BIOLOGICAL ACTIVITY AND ETHNOMEDICINAL USE OF Thymus vulgaris AND Thymus serpyllum

By
Aleksandar Čančarević ,
Aleksandar Čančarević

Faculty of Technology and Metallurgy, Innnovation center, Belgrade, Serbia

Branko Bugarski ,
Branko Bugarski

Faculty of Technology and Metallurgy, Belgrade, Serbia

Katarina Šavikin ,
Katarina Šavikin

Institute for Medicinal Plants Research ,,Dr Josif Pančić’’, Belgrade, Serbia

Gordana Zdunić
Gordana Zdunić

Institute for Medicinal Plants Research ,,Dr Josif Pančić’’, Belgrade, Serbia

Abstract

The Lamiaceae family, which contains about 200 genus and 3000 species, has a cosmopolitan distribution. Plants of this family are rich in essential oils and phenol compounds. Thymus vulgaris (Thyme) is perennial, subshrub plant which belongs to family of Labiates. Calyx and corolla are covered by dense gleaming glands that eradiate essential oil. Leaves or herba, and essential oils are used. Thymus serpyllum (Wild Thyme) is perennial, herbaceous plant. Leaves are evergreen, small and oval. Commitee on Herbal Medicinal Products (HMPC) classifies thyme herba and essential oil as a traditional herbal medicine used as expectorant in cough associated with cold. It is used in folk medicine to treat many diseases, including respiratory disease (cough pertussis, bronchitis and asthma), and has analgesic properties. Wild Thyme is approved for use in treatment of cough and bronchitis. It is unproven to treat kidney and bladder disorders. It is also used internally for dysmenorrheal, colic-like pain, and whooping cough. Thymol and carvacrol from essential oils of Thyme and Wild Thyme inhibit lipid peroxidation and manifest strong antimicrobial activity against different kinds of microorganisms. All the aromatic and medicinal plants available worldwide have been used for their preservative and medicinal values. Polyphenolic phytochemicals in traditionally used medicinal plants act as powerful antioxidants, which aroused an increasing interest in their application in functional food development. Recently, there has been growing considerable interest in extracts and essential oils of aromatic plants for the development of alternative food additives, in order to prevent the growth of food-borne pathogens or to delay the onset of food spoilage.

References

. PDR for Herbal Medicines/Wild Thyme. (2004). Thompson PDR 3th Edition.
Ahmad, A. M., Khokhar, I., Ahmad, I., Kashmiri, M. A., Adnan, A., & Ahmad, M. (2006). Study of antimicrobial activity and composition by GC/MS spectroscopic analysis of the essential oil of Thymus serpyllum. Internet Journal of Food Safety, 5, 56–60.
Allan, G. (1999). An illustrated colour text clinical biochemistry. In UK (pp. 106–114).
Aziz, S., & Rehman, H. (2008). Studies on the chemical constituens of Thymus serpyllum, Turk. J. Chem, 32, 605–614.
Bassole, I., Lamien-Meda, A., Bayala, B., Tirogo, S., Franz, C., Novak, J., Nebie, R., & Dicko, M. (2010). Composition and antimicrobial activities of Lippia multiflora Moldenke. Molecules, 15(11), 7825–7839.
Chizzola, R., Michitsch, H., & Franz, C. (2008). Antioxidative properties of Thymus vulgaris leaves: Ccomparison of different extracts and essential oils chemotypes. J. Agric. Food Chem, 56(16, 6897–6904.
Community herbal monograph on Thymus vulgaris L. and Thymus zygis L., herba. (2007). European Medicines Agency Evaluation of Medicines for Human Use London.
Delgado, B., Fernandez, P., Palop, A., & Periago, P. (2004). Effest of thymol and cimen on Bacillus cereus vegetative cells evaluated through the use of frequency distributions. Food Microbiol, 21(3), 327–334.
Fayad, N. K., Obaidi, O. H., Noor, T. H., & Ezzat, M. O. (2013). Water and alcohol extraction of Thyme plant (Thymus vulgaris) and activity study against bacteria, tumors and used as anti-oxidant in margarine manufacture. Innovative Systems Design and Engineering, 4(1), 41–51.
Gomez, J., Lopez, A., Lopez, M., Gomez, M., & Montero, P. (2010). Biodegradable gelatin-chitozan films incorporated with essential oils as antimikrobial agents for fish preservation. Food Microbiol, 27(7), 889–896.
Gorunović, M., & Lukić, P. (2001). Farmakognozija, Zavod za grafičku tehniku TMF-a. Zavod Za Grafičku Tehniku TMF-a.
Grande, S., Bogani, P., Saizieu, A., Schueler, G., Galli, C., & Visioli, F. (2004). Vasomodulating potential of Nediterranean wild plant extracts. J. Agric. Food Chem, 52, 5021–5026.
Hashim, S., & Gamil, M. (1988). Plants and herbs between the Iraqi folk medicine and scientific research. In Dar revolution of Press and Publication.
Hashmi, L. S. A., Hossain, M. A., Weli, A. M., Al-Riyami, Q., & Al-Sabahi, J. N. (2013). Gas chromatography-mass spectrometry analysis of different organic crude extracts from the local medicinal plant of Thymus vulgaris. Asian Pacific Journal of Tropical Biomedicine, 3(1), 69-73 15.
Jančić, R. (2005). Botanika farmaceutika, Službeni list SRJ. Službeni List SRJ.
Kulisić, T., Radonić, A., & Miloš, M. (2005). Antioxidant properties of thyme (Thymus vulgaris L.) and wild thyme (Thymus serpyllum L.) essential oils,Ital. J. Food Sci, 3, 315–324.
Kulisić, T., Uzelac, V., & Miloš, M. (2006). Antioxidant activity of aqueous tea infusions prepared from Oregano, Thyme and Wild Thyme, Food Technol. Biotechnol, 44(4), 485–492.
Lee, S. J., Umano, K., Shibamoto, T., & Lee, K. G. (2005). Identification of volatile components in basil (Ocimum basilicum L.) and thyme leaves (Thymus vulgaris L.) and their antioxidant properties. Food Chem, 91, 131–137.
Lević, J., Čabarkapa, I., Todorović, G., Pavkov, S., Sredanović, S., Galonja, T., & Kostadinović, L. (2011). In vitro antibacterial activity of essential oils from plant family Lamiaceae. Romanian Biotechnological Letters, 16(1), 6034–6041.
Lopez, P., Sanchez, C., Battle, R., & Neri, C. (2007). Vapor-phase activities of cinnamon,t, and oregano essential oils and key constituents against foodborne microorganisms. J. Agric. Food Chem, 55, 4348–4356.
Margaris, N., Koedam, A., & Vokou, D. (1982). Aromatic Plants: Basic and Applied Aspects, Martinus Nihoff Publishers. Martinus Nihoff Publishers, 13, 271.
Mihailović-Stanojević, N., Belščak-Cvitanović, A., Grujić-Milanović, J., Ivanov, M., Jovović, D., Bugarski, D., & Miloradović, Z. (2013). Antioxidant and antihypertensive activity of extract from Thymus serpyllum L. in experimental hypertension. Plant Foods for Human Nutrition, 68(3), 235–240.
Mihalak, D., Frece, J., Slavica, A., Delaš, F., Pavlović, H., & Markov, K. (2013). The effects of wild thyme (Thymus serpyllum L.) essential oil components against ochratoxin-producing Aspergilli. Archives of Industrial Hygiene and Toxicology, 63(4), 457–462.
Miuora, K., Kikuzaki, H., & Nakatani, N. (2002). Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. J. Agric. Food Chem, 50, 1845–1851.
Nilforoushzadeh, M. A., Shirani, L., Zolfaghari, A., Saberi, S., Siadat, A. H., & Mahmoudi, M. (2008). Comparasion of Thymus vulgaris, Achillea millefolium and 16 propolis hydroalcoholic extracts versus systemic glucantime in the treatment of cutaneous leishmaniasis in balb/c mice. J. Vector Borne Dis, 45, 301–306.
Petrović, S., Ristić, M., Babović, N., Lazić, M., Francišković, M., & Petrović, S. (2013). Hemijski sastav i antioksidativna aktivnost etarskog ulja Thymus serpyllum L., Hemijska industrija. Hemijska Industrija, Beograd.
Rizk, A. M. (1986). The Phyto Chemistry of Flora of Qatar. In King Print Of Richmond.
Shu, B. L. X. (1994). Thymus Linnaeus. Flora of China, 17, 233–236.
Soković, M., Glamočlija, J., Marin, P. D., Brkić, D., & Griensven, L. J. L. D. (2010). Antibacterial effects of the essential oils of commonly consumed medicinal herbs an in vitro model. Molecules, 15(11), 7532–7546.
Stepanović, B., & Radanović, D. (2011). Tehnologija gajenja lekovitog i aromatičnog bilja u Srbiji. In Ton Plus.
Youdim, K. A., Dormanand, H. J. D., & Deans, S. G. (1999). The antioxidant effectiveness of thyme oil, α-tocopherol and ascorbyl palmitate on evening primrose oil oxidation. J. Essent. Oil Res, 11, 643–648.
Zheng, W., & Wang, S. Y. (2001). Antioxidant activity and phenolic compounds in select herbs. J. Agric. Food Chem, 49, 5165–5170.

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