The aims of the present research were to develop and characterize 4-hydroxycoumarin-loaded liposomes via the determination of encapsulation efficiency, antioxidant capacity, vesicle size, polydispersity index (PDI), zeta potential, conductivity, mobility, density, surface tension, viscosity, and 60-day storage stability. The encapsulation efficien...

By Aleksandra Jovanović, Edina Avdović, Ana Plećić, Vojislav Ćirić, Branko Bugarski, Zoran Marković

Vaccinium myrtillus L. (bilberry, Ericaceae), a perennial, wild, and small deciduous shrub that grows in the mountains and forests of Europe. The leaf extracts are widely used in traditional medicine due to their astringent, antiseptic, antioxidant, anti-inflammatory, hypolipidemic, and hypoglycemic activities. Microwave-assisted extraction provide...

By Muna Elferjane, Petar Batinić, Natalija Čutović, Milena Milošević, Vojislav Ćirić, Aleksandar Marinković, Aleksandra Jovanović

Plants are natural products responsible for many biological activities. It is quite common to use plants that attract attention with their nutritive properties within the scope of complementary medicine. Matricaria species, which have naturally distributed, are among the plants used in traditional medicine. Revealing the biological activities of p...

By Hasan Hüseyin Yaz, İmran Uysal, Abdullah Ozan Polat, Falah Saleh Mohammed, Mustafa Sevindik

This study was designed to investigate the impact of different extraction methods (ultrasound-assisted extraction, maceration, and microwave-assisted extraction) on the content of polyphenols and biological activities of leaf extract of Paeonia daurica subsp. daurica collected in Južni Kučaj (Serbia). The total polyphenol and flavonoid c...

By Petar Batinic, Natalija Cutovic, Aleksandra Jovanović, Dejan Stojković, Gokhan Zengin, Tamara Carević, Željana Prijić, Aleksandar Marinković, Tatjana Marković

Traditional plant extraction methods commonly employ hazardous solvents that threaten human health. Considering these, the study sought to explore the efficacy of seven distinct types of apple cider vinegar (ACV) as an alternative solvent for isolating polyphenols from dry elderberries as a raw material. In the pursuit of identifying the most suita...

By Zorana Mutavski, Mirjana Sulejmanović, Sladjana Krivošija, Changhui Zhao, Senka Vidović

Steppe peony (Paeonia tenuifolia L., Paeoniaceae) is a perennial, herbaceous plant species which has been widely known for its medicinal use. This study is aimed at the development of P. tenuifolia petal dry methanolic extract-loaded liposomes and the determination of their antioxidant activity. The liposomes were prepared with three different phos...

By Natalija Cutovic, Tatjana Marković, Ana Žugić, Petar Batinic, Branko Bugarski, Aleksandra Jovanović

Relatively simple, but very reliable, one-step qualitative/quantitative HPLC analysis of four key flavonoids, and a phenolcarboxylic acid, has been introduced. For substrate/sample preparations, either triple percolations, using 70% ethanol-water (V/V), or/and ultrasonic bath methanol extractions, were carried out to obtain the desired isolates yi...

By Vanja Tadic, Dragica Bojovic, Goran Marković, Ivana Nešić, Ana Žugić

In this study, antimicrobial activity of essential oils extracted from the aerial flowering parts (herbs) of Hyssopus officinalis subsp. aristatus (Godr.) Nyman (Lamiaceae) collected from five different locations in Montenegro, or purchased in Serbia, were investigated. In addition, their antibacterial activity in combination with antibiotics was s...

By Tijana Mićović, Dušan Ušjak, Marina Milenković, Stevan Samardžić, Zoran Maksimović

Paeonia peregrina Mill. and Paeonia tenuifolia L. are endangered species of herbaceous plants with high ornamental and medicinal values. There are a few natural habitats in Serbia where these plants spontaneously grow: Krivi Vir, Skrobnica, Golina, Pirot, Deliblato Sands, and Sokobanja, in the municipality of Knjaževac. In July 2021, the symp...

By Sara Mikić, Tatjana Marković, Nina Vučković, Željana Prijić, Jingqi Xue

Dental caries is one of the most prevalent public health problems. It is caused by a well-organized bacterial structure i.e., biofilm, where the cariogenic bacteria Streptococcus mutans is recognized as the primary pathogenic factor. Furthermore, the first phase of dental biofilm onset is predominantly associated to bacteria of the Streptococcus g...

By Milica Nemoda, Biljana Nikolić, Tatjana Vukotić, Dragana Rakašević, Dejan Marković, Milica Jovičić, Jelena Marinković