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Research Article

Assessment of antioxidant and hepatoprotective potential of Satureja montana extracts against CCl4 induced liver damage

By
Tatjana Ćebović ,
Tatjana Ćebović

Department of Biochemistry, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

Jelena Vladić ,
Jelena Vladić
Contact Jelena Vladić

Department of Biotechnological and Pharmaceutical Engineering, Faculty of Technology, University of Novi Sad, Novi Sad, Serbia

Aleksandra Gavarić ,
Aleksandra Gavarić

Department of Biotechnological and Pharmaceutical Engineering, Faculty of Technology, University of Novi Sad, Novi Sad, Serbia

Zoran Zekanović ,
Zoran Zekanović

Department of Biotechnological and Pharmaceutical Engineering, Faculty of Technology, University of Novi Sad, Novi Sad, Serbia

Senka Vidović
Senka Vidović

Department of Biotechnological and Pharmaceutical Engineering, Faculty of Technology, University of Novi Sad, Novi Sad, Serbia

Abstract

The influence of Satureja montana extracts on several liver biochemical parameters in mice administered with carbon tetrachloride was estimated. In vivo investigation of antioxidant properties of S. montana extracts encompassed monitoring of biochemical parameters (derived from liver homogenate and blood hydrolyzate) and examination of potential hepatoprotective effect after intoxication with carbon tetrachloride. Biochemical tests included determination of activity of several antioxidant enzymes: xanthine oxidase, catalase, peroxidase, glutathione peroxidase, amount of reduced glutathione and intensity of lipid peroxidation. In order to obtain data about the potent hepatoprotective effect of examined extracts, the following parameters were determined: aspartate aminotransferase, alanine aminotransferase, bilirubin, hepatic DNA and hydroxyprolin. Results of this study demonstrate that S. montana extracts inhibited the hepatotoxicity produced by carbon tetrachloride administration most probably through activation of physiological common defense mechanisms.


 

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