Lady’s mantle (Alchemilla vulgaris L. syn. Alchemilla xanthochlora Rothm., Rosaceae) has been commonly used in folk medicine to heal inflammations in the mouth, bleeding of the nose, furuncules, gynaecological (menorrhagia and dysmenorrhoea), and gastrointestinal disorders. Although therapeutic indications for Lady’s mantle are non-specific diarrhoea and gastrointestinal complaints, it has been reported to exert, as well, a variety of biological activities, including wound healing, antimicrobial, neuroprotective, gastroprotective, cytotoxic, and antioxidant. Lady’s mantle presents a valuable source of natural bioactive compounds, mostly phenolic compounds – a large amount of tannins, phenolcarboxylic acids, and flavonoids, being responsible for the abovementioned effects. In this work, a literature review of biological properties, investigated in in vitro and in vivo experiments in regard to the determined chemical profile is presented. In addition, the data reported are discussed, and the directions for further investigations are proposed.
Abdel-Daim, M. M., Aleya, L., El-Bialy, B. E., Abushouk, A. I., Alkahtani, S., & Alarifi, S. (2019). The ameliorative effects of ceftriaxone and vitamin e against cisplatin-induced nephrotoxicity. Environ. Sci. Pollut. Res, 26, 15248–15254.
Amadeu, T. P., Coulomb, B., Desmoulière, A., & Costa, A. M. (2003). Cutaneous wound healing: myofibroblastic differentiation and in vitro models. Int. J. Low. Extrem. Wounds, 2(2), 60–68.
Asnaashari, S., Dastmalchi, S., & Javadzadeh, Y. (2018). Gastroprotective effects of herbal medicines (roots. Int. J. Food Prop, 21(1), 901–919.
Atef, N. M., Shanab, S. M., Negm, S. I., & A, Y. A. (2019). Evaluation of antimicrobial activity of some plant extracts against antibiotic susceptible and resistant bacterial strains causing wound infection. Bull. Nat. Res. Cent, 43, 144.
Blumental, M., Busse, W. R., Goldberg, A., Gruenwald, J., Hall, T., Riggins, W., Rister, R. S., Klein, S., & Tyler, V. E. (1998). The Complete German Commission E Monographs. In Therapeutic Guide to Herbal Medicines. Cooperation with Integrative Medicine Communications.
Borodin, Y. I., Selyatitskaya, V. G., Obukhoca, L. A., Palchikova, N. A., Odintsov, S. V., & Kukushkina, T. A. (1999). Effects of polyphenol compounds from Alchemilla vulgaris on morphofunctional state of thyroid gland in rats exposed to low temperature. Bull. Exp. Biol. Med, 127, 637–639.
Boroja, T., Mihailović, V., Katanić, J., Pan, S.-P., Nikles, S., Imbimbo, P., Monti, D. M., Stanković, N., Stanković, S., & Bauer, R. (2018). The biological activities of roots and aerial parts of Alchemilla vulgaris L. S. Afr. J. Bot, 116, 175–184.
Carballo-Carbajal, I., Laguna, A., Romero-Giménez, J., Cuadros, T., Bové, J., Martinez-Vicente, M., Parent, A., Gonzalez-Sepulveda, M., Peñuelas, N., Torra, A., Rodríguez-Galván, B., Ballabio, A., Hasegawa, T., Bortolozzi, A., Gelpi, E., & Vila, M. (2019). Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis. Nat. Commun, 10, 973.
Choi, J., Park, Y.-G., Yun, M.-S., & Seol, J.-W. (2018). Effect of herbal mixture composed of Alchemilla vulgaris and Mimosa on wound healing process. Biomed. Pharmacother, 106, 326–332.
Denaro, M., Smeriglio, A., Barreca, D., Francesco, C., Occhiuto, C., Milano, G., & Trombetta, D. (2020). Antiviral activity of plants and their isolated bioactive compounds: An update. Phytother. Res, 34(4), 742–768.
Ducksteina, S. M., Lottera, E. M., Meyera, U., Lindequistb, U., & Stintzinga, F. C. (2012). Phenolic Constituents from Alchemilla vulgaris L. and Alchemilla mollis (Buser. Rothm. at Different Dates of Harvest. Z. Naturforsch. C. J. Biosci, 67(1–2), 529–540.
Ergene, B., Acikara Bahadir, Ö., Bakar, F., Saltan, G., & Nebioǧlu, S. (2010). Antioxidant activity and phytochemical analysis of Alchemilla persica Rothm. J. Fac. Pharm. Ankara, 39(2), 145–154.
Evans, W. C., Evans, D., & Trease, G. E. (2009). A taxonomic approach to the study of medicinal planta and animal-derived drugs. In Trease and Evans pharmacognosy.
Filippova, E. I. (2017). Antiviral Activity of Lady’s Mantle (Alchemilla vulgaris L.) Extracts against Orthopoxviruses. B. Exp. Biol. Med, 163(3), 374–377.
Ghedira, K., Goetz, P., & Jeune, R. L. (2012). Alchemilla vulgaris: Alchemille (Rosaceae. Phytotherapie, 10, 263–266.
Gibbons, S. (2003). An overview of plant extracts as potential therapeutics. Expert Opinion on Therapeutic Patents, 13(4), 489–497.
Hager. (1979). Handbuch der pharmazeutischen praxis, Bd. 6, Teil C. Springer-Verlag, Berlin.
Heinrich, M., Barnes, J., Gibbons, S., & Williamson, E. (2012). Production, standardization and quality control. In Fundamentals of Pharmacognosy and Phytotherapy.
Herbal Remedies, P. D. R. (2005). Medicinal Economics Company. 78–79.
Hou, Y., Dan, X., Babbar, M., Yong, W., Hasselbalch, S. G., Croteau, D. L., & Bohr, V. A. (2019). Ageing as a risk factor for neurodegenerative disease. Nat. Rev. Neurol, 15(10), 565–581.
I., Ž., Arsić, I., Tadić, V., Mišić, D., Petrović, S., Jovanović, S., Đorđrvić, S., Ivanović, J., Stamenić, M., Milovanović, S., Žugić, A., Savić, S., Ašanin, J., Miličić-Marić, N., & Tasić-Kostov, M. (2016). Bioactive semisolid and solid phytopreparations.
Ibrahim, B., Suleyman, G., & Enginar, H. (2018). Study on Optimum Extraction Conditions for Galantamine from Galanthus woronowii L. Bulbs. J. Med. Plants, 24(4), 1–12.
Ilić-Stojanović, S., Nikolić, V., Kundaković, T., Savić, I., Savić-Gajić, I., Jocić, E., & Nikolić, L. (2018). Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. Extract. Int. J. Polym. Mater, 67(9), 553–563.
Jhong, C.-H., Riyaphan, J., Lin, S.-H., Chia, Y.-C., & Weng, C.-F. (2015). Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silico. Biofactors, 41(4), 242–251.
Jimenez, F., Mitts, T. F., Liu, K., Wang, Y., & Hinek, A. (2006). Ellagic and tannic acids protect newly synthesized elastic fibers from premature enzymatic degradation in dermal fibroblast cultures. J. Investig. Dermatol, 126(6), 1272–1280.
Jurić, T., Katanić Stanković, J. S., Rosić, G., Selaković, D., Joksimović, J., Mišić, D., Stanković, V., & Mihailović, V. (2020). Protective effects of Alchemilla vulgaris L. extracts against cisplatin-induced toxicological alterations in rats. S. Afr. J. Bot, 128, 141–151.
Kim, Y., & Uyama, H. (2005). Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective. Cell. Mol. Life Sci, 62(15), 1707–1723.
Krivokuća, M., Niketic, M., Milenković, M., Golić, N., Masia, C., Scaltrito, M., Sisto, F., & Kundaković, T. (2015). Anti- Helicobacter Pylori Activity of Four Alchemilla Species (Rosaceae. Nat. Pro. Comm, 10(8), 1369–1371.
Kuete, V. (2010). Potential of Cameroonian Plants and Derived Products against Microbial Infections: A Review. Planta Med, 76(14), 1479–1491.
Lalkovičová, M., & Danielisová, V. (2016). Neuroprotection and antioxidants. Neural. Regen. Res, 11(6), 865–874.
Lanas, A., & Chan, F. K. L. (2017). Peptic ulcer disease. The Lancet, 390(10094), 613–624.
Lee, S. Y., Baek, N., & Nam, T. (2016). Natural, semisynthetic and synthetic tyrosinase inhibitors. J. Enzyme Inhib. Med. Chem, 31(1), 1–13.
Malfertheiner, P., Chan, F. K., & McColl, K. E. (2009). Peptic ulcer disease. The Lancet, 374(9699), 1449–1461.
Mandrone, M., Coqueiro, A., Poli, F., Antognoni, F., & Hae Choi, Y. (2018). Identification of a collagenase-inhibiting flavonoid from Alchemilla vulgaris using NMR-based metabolomics. Planta Med, 84(12–13), 941–946.
Martinez-Gonzalez, A. I., Dıaz-Sanchez, A. G., Rosa, A., Bustos-Jaimes, I., & Alvarez-Parrilla, E. (2019). Inhibition of α - amylase by favonoids: Structure–activity relationship (SAR. Spectrochim. Acta A Mol. Biomol. Spectrosc, 206, 437–447.
Micov, A., & Pecikoza, U. (2020). Lekovi u lečenju demencija - unapred izgubljena bitka? Arhiv Za Farmaciju, 70(2), 55–68.
Monograph, E. S. C. O. P. H. (2013). The Scientific Foundation for Herbal Medicinal Products. Alchemilla / Lady’s Mantle, European Scientific Cooperative on Phytotherapy.
Neagu, E., Paun, G., Albu, C., & Radu, G. C. (2015). Assessment of acetylcholinesterase and tyrosinase inhibitory and antioxidant activity of Alchemilla vulgaris and Filipendula ulmaria extracts. J. Taiwan Inst. Chem. E, 52, 1–6.
Ojha, S., Venkataraman, B., Kurdi, A., Mahgoub, E., Sadek, B., & Rajesh, M. (2016). Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity. Oxid. Med. Cell. Longev, 4320374.
Oun, R., Moussa, Y. E., & Wheate, N. J. (2018). The side effects of platinum-based chemotherapy drugs: a review for chemists. Dalton T, 47(19), 6645–6653.
Özbilgin, S., Özbek, H., Kirmizi, N. I., Öz, B., Kurtul, E., Özrenk, B., Saltan Işcan, G., & Bahadir Acikara, O. (2019). Evaluation of the Antidiabetic Activity of Alchemilla persica Rothm. in Mice with Diabetes Induced by Alloxan. Turkish Journal of Pharmaceutical Sciences, 16(3), 261-264,.
Pawlaczyk, I., Czerchawski, L., Pilecki, W., Lamer-Zarawska, E., & Gancarz, R. (2009). Polyphenolicpolysaccharide compounds from selected medicinal plants of Asteraceae and Rosaceae families: chemical characterization and blood anticoagulant activity. Carbohyd. Polym, 77(3), 568–575.
Petrović, S. (2019). Biljni i tradicionalni biljni lekovi, monografije EU i lista EU. Arhiv Za Farmaciju, 69(4), 221–269.
Seffo, S. (2020). Extracts Of Alchemilla Vulgaris and Salvia Officinalis L. Against Some Bacterial Strains Causing Food Poisoning Diseases. Internation. J. Academ. Scien. Res, 8, 50–55.
Shilova, I. V., Suslov, N. I., Samylina, I. A., Baeva, V. M., Lazareva, N. B., & Mazin, E. V. (2020). Neuroprotective Properties of Common Lady’s Mantle Infusion. Pharm. Chem. J, 53(11), 1059–1062.
Si, Y.-X., Yin, S.-J., Oh, S., Wang, Z.-J., Ye, S., Yan, L., Yang, J.-M., Park, Y.-D., Lee, J., & Qian, G.-Y. (2012). An Integrated Study of Tyrosinase Inhibition by Rutin: Progress using a Computational Simulation. J. Biomol. Struct. Dyn, 29(5), 999–1012.
Singer, A. J., & Clark, R. A. (1999). Cutaneous wound healing. N. Engl. J. Med, 341(10), 738–746.
Slanc, P., Doljak, B., Kreft, S., Lunder, M., Janes, D., & Strukelj, B. (2009). Screening of selected food and medicinal plant extracts for pancreatic lipase inhibition. Phytother. Res, 23(6), 874–877.
Tadić, V., Žugić, A., & I, A. (2014). Multi-target herbal preparation. In Supercritical CO2 extractions, Polish Foundations of the Opportunities Industralization Centers „OIC Poland“ (pp. 99–121).
Tasić-Kostov, M. A., I., P., D., S., S., N., S., N., S., & Tadić, V. (2019). Towards a modern approach to traditional use: in vitro and in vivo evaluation of Alchemilla vulgaris L. Gel Wound Healing Potential. J. Ethnopharmacol, 238, 111789.
Tucakov, J. (1997). Lečenje Biljem.
Valcheva-Kuzmanova, S., Denev, P., Eftimov, M., Georgieva, A., Kuzmanova, V., Kuzmanov, A., Kuzmanov, K., & Tzaneva, M. (2019). Protective effects of Aronia melanocarpa juices either alone or combined with extracts from Rosa canina or Alchemilla vulgaris in a rat model of indomethacin-induced gastric ulcers. Food Chem. Toxicol, 132, 110739.
Vlaisavljević, S., Jelača, S., Zengin, G., Mimica-Dukić, N., Berežni, S., Miljić, M., & Stevanović, Z. D. (2019). Alchemilla vulgaris agg.(Lady’s mantle) from Central Balkan: antioxidant, anticancer and enzyme inhibition properties. RSC Adv, 9(64), 37474–37483.
Yilmazer-musa, M., Michels, A. J., Schneider, E., & Frei, B. (2012). Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity. J. Agric. Food Chem, 60(36), 8924–8929.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
