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Antifungal activity of the essential oil from Artemisia santonicum and its constituent isogeranic acid

By
Jovana Stankov-Jovanović ,
Jovana Stankov-Jovanović
Contact Jovana Stankov-Jovanović

Department of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Serbia

Miroslav Novaković ,
Miroslav Novaković

Department of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Serbia

Miroslav Novaković ,
Miroslav Novaković

Faculty of Chemistry, University of Belgrade, Belgrade, Serbia

Vele Tešević ,
Vele Tešević

Dept. of Plant Physiology, Institute for Biological Research “Siniša Stankovic” , University of Belgrade, Belgrade, Serbia

Gordana Zdunić ,
Gordana Zdunić

Institute for Medicinal Plant Research “Dr. Josif Pančić”, Belgrade, Serbia

Zora Dajić Stevanović ,
Zora Dajić Stevanović

Faculty of Agriculture, University of Belgrade, Belgrade, Serbia

Dejan Gođevac
Dejan Gođevac

Department of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Serbia

Abstract

This study represents a continuation of exploring of the biological activities of the Artemisia santonicum essential oil. The previous investigation was focused on the antibacterial, antibiofilm, and antiquorum activities of A. santonicum essential oil and isogeranic acid as the main antibacterial constituent. The present study describes their antifungal activity. The antifungal activity of the A. santonicum essential oil was tested against eight fungi isolates, whereas antifungal effects of isogeranic acid were studied using four fungi species, because of the limited quantities of the isolated compound. The results were compared to the commercial antimycotics, bifonazole and ketoconazole. Antifungal activity of isogeranic acid against all tested fungi was significantly higher in comparison to the essential oil and the both controls.


 

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