Considering the increase of the elderly population in recent years, the growing prevalence of age-related neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD) and Parkinson’s disease (PD), has become one of the leading healthcare problems. Currently, available therapies for AD and PD are still limited, while medicinal p...

By Ana Alimpić-Aradski, Mariana Oalđe-Pavlović, Smiljana Janković, Petar D.Marin, Sonja Duletić-Laušević

This study aimed to assess the antineurodegenerative and antioxidant activity of Helichrysum plicatum flower extract, as well as to identify extract ingredients with acceptable pharmacokinetic parameters such as gastrointestinal absorption, blood-brain barrier permeation, and P-glycoprotein-mediated effusion for optimal therapeutic brain exposure. ...

By Miloš Jovanović, Zorica Drinić, Dubravka Bigović, Ana Alimpić-Aradski, Sonja Duletić-Laušević, Katarina Šavikin

<i>Ocimum basilicum<i> (sweet basil) and <i>Laurus nobilis</i> (bay leaves or laurel) have been used in traditional medicine for centuries, and also extensively employed as spices for adding aroma and flavor to various food products. <i>Citrus reticulata</i>  (mandarin) is mainly used in food industry for ju...

By Sonja Duletić-Laušević, Mariana Oalđe, Ana Alimpić-Aradski

Biological activities of Sorbus aucuparia L. leaves extract was tested in our study. Antineurodegenerative activity was evaluated by acetylcholinesterase (AChE) and tyrosinase (TYR) inhibitory activity assays while antioxidant activity was by tested using four different assays. In all antioxidant test we noticed concentration dependent activity of ...

By Katarina Šavikin, Gordan Zdunić, Ana Alimpić, Dubravka Bigović, Dejan Pljevljakušić, Sonja Duletić-Laušević

Different biological activities of Hypericum perforatum L. dry extract was tested in this study. Antioxidant activity was evaluated by four different assays. Antineurodegenerative activity was tested using acetylcholinesterase (AChE) and tyrosinase inhibitory activity assays. In all four antioxidant assays, concentration dependent manner was notice...

By Katarina Šavikin, Ana Alimpić, Gordana Zdunić, Jelena Živković, Teodora Janković, Nebojša Menković, Sonja Duletić-Laušević