Mushrooms for ages have been used by humans, not only as a source of food, but medicinal resources as well. They were used as a part of traditional medicine, first of all in the civilizations of the East and recentlly in Western civilizations. The mushrooms constitute 16,000 species worldwide with more than 2000 species identified as safe. Among these mushrooms, 1000 are edible, while others have been used as a source of biofuel, in medicinal formulation, as biochemicals, and for other purposes. Mushrooms have also huge potential, such as a “mushroom pharmaceuticals” wuth 130 medicinal functions. Therefore, they have been considered as potential source of antioxidant, antitumor, antiviral, antimicrobial, and immunomodulatory agents. This review focuses on the antimicrobial and analgetic activities of some medicinal mushrooms.
Alves, M., Ferreira, I., Dias, J., Teixeira, V., Martins, A. and P., & M. (2012). A Review on Antimicrobial Activity of Mushroom (Basidiomycetes. Extracts and Isolated Compounds, Planta Medica, 78(16), 1707–1718.
Alves, M., Ferreira, I., Dias, J., Teixeira, V., Martins, A., & Pintado, M. (2013). A Review on Antifungal Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds. Current Topics in Medicinal Chemistry, 13(21), 2648–2659.
Alves, M., Ferreira, I., Martins, A., & Pintado, M. (2012). Antimicrobial activity of wild mushroom extracts against clinical isolates resistant to different antibiotics. Journal of Applied Microbiology, 113(2), 466–475.
Ameri, A., Vaidya, G., J., & Deokule, S. S. (2011). In vitro evaluation of anti-staphylococcal activity of Ganoderma lucidum, Ganoderma praelongum and Ganoderma resinaceum from Pune, India. African Journal of Microbiology Research, 5.
B., & Regula, J. (2012). Health-promoting potential of edible macromycetes under special consideration of polysaccharides: a review. European Food Research and Technology, 234(3), 369–380.
Baggio, C. H., Freitas, C. S., Marcon, R., Paula Werner, M. F., Rae, G. A., Smiderle, F. R., Sassaki, G. L., Iacomini, M., Marques, M. C. A., & Santos, A. R. S. (2012). Antinociception of /beta-d-glucan from Pleurotus pulmonarius is possibly related to protein kinase C inhibition. International Journal of Biological Macromolecules, 50(3), 872–877.
Baggio, C. H., Freitas, C. S., Martins, D. F., Mazzardo, L., Smiderle, F. R., Sassaki, G. L., Iacomini, M., Marques, M. C. A., & Santos, A. R. S. (2010). Antinociceptive effects of (1→3),(1→6)-linked β-glucan isolated from Pleurotus pulmonarius in models of acute and neuropathic pain in mice: Evidence for a role for glutamatergic receptors and cytokine pathways. The Journal of Pain, 11(10), 965–971.
Barros, L., Calhelha, R. C., Vaz, J. A., Ferreira, I. C. F. R., Baptista, P., & Estevinho, L. M. (2007). Antimicrobial activity and bioactive compounds of Portuguese wild edible mushrooms methanolic extracts. European Food Research and Technology, 225(2), 151–156.
Baumgartner, K., Fujiyoshi, P., Foster, G. D., & Bailey, A. M. (2010). Agrobacterium tumefaciens-Mediated Transformation for Investigation of Somatic Recombination in the Fungal Pathogen Armillaria mellea. Applied and Environmental Microbiology, 76(24), 7990–7996.
Blackwell, M. (2011). The Fungi: 1, 2, 3 ... 5.1 million species? American Journal of Botany, 98(3), 426–438.
Bohnert, M., Nützmann, H.-W., Schroeckh, V., Horn, F., Dahse, H.-M., Brakhage, A. A., & Hoffmeister, D. (2014). Cytotoxic and antifungal activities of melleolide antibiotics follow dissimilar structure–activity relationships. Phytochemistry, 105, 101–108.
Brock Biology Of Microorganisms. (2006).
Bryden, W. L. (2012). Mycotoxin contamination of the feed supply chain: Implications for animal productivity and feed security. Animal Feed Science and Technology, 173(1–2), 134–158.
Centko, R. M., Ramon-Garcia, S., Taylor, T., Patrick, B. O., Thompson, C. J., Miao, V. P., & Andersen, R. J. (2012). Ramariolides A–D, Antimycobacterial Butenolides Isolated from the Mushroom Ramaria cystidiophora. Journal of Natural Products, 75(12), 2178–2182.
Chang, S.-T., & Wasser, S. P. (2012). The Role of CulinaryMedicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health. International Journal of Medicinal Mushrooms, 14(2), 95–134.
Cheung, P. C. K. (2010). The nutritional and health benefits of mushrooms: Nutritional and health benefits of mushrooms. Nutrition Bulletin, 35(4), 292–299.
Chu, K., Xia, L., & Ng, T. (2005). Pleurostrin, an antifungal peptide from the oyster mushroom. Peptides, 26(11), 2098–2103.
Fan, L., Pan, H., Thomaz Soccol, A., Pandey, A., & Soccol, C. (2006). Advances in Mushroom Research in the Last Decade. Food Technology and Biotechnology, 44.
Gargano, M. L., Griensven, L. J. L. D., Isikhuemhen, O. S., Lindequist, U., Venturella, G., & Wasser, S. P. (2017). Medicinal mushrooms: Valuable biological resources of high exploitation potential. In Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology (Vol. 151, Issue 3, pp. 548–565).
Giri, S., Biswas, G., Pradhan, P., Mandal, C., S., & Acharya, K. (2012). Antimicrobial Activities of Basidiocarps of Wild Edible Mushrooms of West Bengal, India. International Journal of PharmTech Research, 4, 1554–1560.
Glamoclija, J., Stojkovic, D., Nikolic, M., Ciric, A., Reis, F. S., Barros, L., Ferreira, I. C. F. R., & Sokovic, M. (2015). A comparative study on edible Agaricus mushrooms as functional foods. Food & Function, 6(6), 1900–1910.
Griensven, L., Smiderle, F., Baggio, C., Henquet, M., Verhoeven, H., & Ventola, C. L. (2017). Mushroom extracts suppress pain: a critical approach. The 9 Th Internationall Medicinal Mushrooms Conference, Book of Abstracts, 40(4), 9.
Harikrishnan, R., Balasundaram, C., & Heo, M.-S. (2011). Diet enriched with mushroom Phellinus linteus extract enhances the growth, innate immune response, and disease resistance of kelp grouper, Epinephelus bruneus against vibriosis. Fish & Shellfish Immunology, 30(1), 128–134.
Harikrishnan, R., Balasundaram, C., & Heo, M.-S. (2012). Effect of Inonotus obliquus enriched diet on hematology, immune response, and disease protection in kelp grouper, Epinephelus bruneus against Vibrio harveyi. Aquaculture, 344-349(Supplement C, 48–53.
Havlickova, B., Czaika, V. A., & Friedrich, M. (2008). Epidemiological trends in skin mycoses worldwide. Mycoses, 51, 2–15.
Hearst, R., Nelson, D., McCollum, G., Millar, B. C., Maeda, Y., Goldsmith, C. E., Rooney, P. J., Loughrey, A., Rao, J., & Moore, J. E. (2009). An examination of antibacterial and antifungal properties of constituents of Shiitake (Lentinula edodes) and Oyster (Pleurotus ostreatus) mushrooms. Complementary Therapies in Clinical Practice, 15(1), 5–7.
Heleno, S. A., Ferreira, I. C., Esteves, A. P., Ciric, A., Glamoclija, J., Martins, A., Sokovic, M., & Queiroz, M. J. R. (2013). Antimicrobial and demelanizing activity of Ganoderma lucidum extract, p-hydroxybenzoic and cinnamic acids and their synthetic acetylated glucuronide methyl esters. Food and Chemical Toxicology, 58, 95–100.
Heleno, S. A., Stojkovic, D., Barros, L., Glamoclija, J., Sokovic, M., Martins, A., Queiroz, M. J. R., & Ferreira, I. C. (2013). A comparative study of chemical composition, antioxidant and antimicrobial properties of Morchella esculenta (L. Pers. from Portugal and Serbia, Food Research International, 51(1), 236–243.
Hur, J.-M., Yang, C.-H., Han, S.-H., Lee, S.-H., You, Y.-O., Park, J.-C., & Kim, K.-J. (2004). Antibacterial effect of Phellinus linteus against methicillin-resistant Staphylococcus aureus. Fitoterapia, 75(6), 603–605.
I, G. (2017). Medicinal mushrooms: Valuable biological resources of high exploitation potential, Plant Biosystems. An International Journal Dealing with All Aspects of Plant Biology, 151(3), 548–565.
Karaman, M., Jovin, E., Malbaša, R., Matavuly, M., & Popović, M. (2010). Medicinal and edible lignicolous fungi as natural sources of antioxidative and antibacterial agents. Phytotherapy Research, 24(10), 1473–1481.
Karaman, M., Kaisarevic, S., Somborski, J., Kebert, M., & Matavulj, M. (2009). Biological activities of the lignicolous fungus Meripilus giganteus (Pers.: Pers. Karst., Archives of Biological Sciences, 61(4), 853–861.
Karaman, M., Stahl, M., Vulic, J., Vesic, M., & CanadanovicBrunet, J. (2014). Wild-growing lignicolous mushroom species as sources of novel agents with antioxidative and antibacterial potentials. International Journal of Food Sciences and Nutrition, 65(3), 311–319.
Kim, S. P., Moon, E., Nam, S. H., & Friedman, M. (2012). Hericium erinaceus Mushroom Extracts Protect Infected Mice against Salmonella Typhimurium-Induced Liver Damage and Mortality by Stimulation of Innate Immune Cells. Journal of Agricultural and Food Chemistry, 60(22), 5590–5596.
Kirk, P., Cannon, P., David, J., & Stalpers, J. (2008). Ainsworth & Bisby’s Dictionary of the Fungi, CABI. GoogleBooks-ID: IFD4_VFRDdUC. Review Article Lekovite Sirovine, 37, 55.
Komura, D. L., Carbonero, E. R., Gracher, A. H. P., Baggio, C. H., Freitas, C. S., Marcon, R., Santos, A. R., Gorin, P. A., & Iacomini, M. (2010). Structure of Agaricus spp. fucogalactans and their anti-inflammatory and antinociceptive properties. Bioresource Technology, 101(15), 6192–6199.
Kostic, M., Smiljkovic, M., Petrovic, J., Glamoclija, J., Barros, L., Ferreira, I. C. F. R., Ciric, A., & Sokovic, M. (2017). Chemical, nutritive composition and a wide range of bioactive properties of honey mushroom Armillaria mellea (Vahl: Fr. Kummer, Food Funct, 8(9), 3239–3249.
L., K., V., S., R., & Kaviyarasan, V. (2009). Comparative study on the antioxidant, anticancer and antimicrobial property of agaricus bisporus (j. e. lange) imbach before and after boiling. African Journal of Biotechnology, 8, 654–661.
Lindequist, U., Niedermeyer, T. H. J., & Jülich, W.-D. (2005). The Pharmacological Potential of Mushrooms. Evidencebased Complementary and Alternative Medicine, 2(3), 285–299.
M., S., O., L., H., & Anke, T. (2001). Coprinol, a new antibiotic cuparane from a Coprinus species. Zeitschrift Fur Naturforschung. C, Journal of Biosciences, 56(1–2), 31–34.
Moore, J. E. (2009). An examination of antibacterial and antifungal properties of constituents of Shiitake (Lentinula edodes) and Oyster (Pleurotus ostreatus) mushrooms. Complementary Therapies in Clinical Practice, 15(1), 5–7.
Morris, H. J., Llaurado, G., Beltran, Y., Lebeque, Y., Bermudez, R. C., Garcia, N., Gaime-Perraud, I., & Moukha, S. (2017). The Use of Mushrooms in the Development of Functional Foods, Drugs, and Nutraceuticals. In Wild Plants, Mushrooms and Nuts (pp. 123–157).
Muszynska, B., Lojewski, M., Rojowski, J., Opoka, W., & Sulkowska-Ziaja, K. (2015). Natural products of relevance in the prevention and supportive treatment of depression. Psychiatria Polska, 49, 435–453.
Ngai, P. H., Zhao, Z., & Ng, T. (2005). Agrocybin, an antifungal peptide from the edible mushroom Agrocybe cylindracea. Peptides, 26(2), 191–196.
Ozturk, M., Duru, M. E., Kivrak, S., Mercan-Dogan, N., Turkoglu, A., & Ozler, M. A. (2011). In vitro antioxidant, anticholinesterase and antimicrobial activity studies on three Agaricus species with fatty acid compositions and iron contents: A comparative study on the three most edible mushrooms. Food and Chemical Toxicology, 49(6), 1353–1360.
Paterson, R. R., & Lima, N. (2014). Biomedical effects of mushrooms with emphasis on pure compounds. Biomedical Journal, 37(6), 357.
Petrovic, J., Glamoclija, J., Stojkovic, D., Nikolic, M., Ciric, A., Fernandes, A., Ferreira, I. C. F. R., & Sokovic, M. (2014). Bioactive composition, antimicrobial activities and the influence of Agrocybe aegerita (Brig.) Sing on certain quorumsensing-regulated functions and biofilm formation by Pseudomonas aeruginosa. Food Funct, 5(12), 3296–3303.
Petrovic, J., Glamoclija, J., Stojkovic, D. S., Ciric, A., Nikolic, M., Bukvicki, D., Guerzoni, M. E., & Sokovic, M. D. (2013). Laetiporus sulphureus, edible mushroom from Serbia: Investigation on volatile compounds, in vitro antimicrobial activity and in situ control of Aspergillus flavus in tomato paste. Food and Chemical Toxicology, 59, 297–302.
Petrovic, J., Papandreou, M., Glamoclija, J., Ciric, A., Baskakis, C., Proestos, C., Lamari, F., Zoumpoulakis, P., & Sokovic, M. (2014). Different extraction methodologies and their influence on the bioactivity of the wild edible mushroom Laetiporus sulphureus (Bull.) Murrill. Food Funct, 5(11), 2948–2960.
Petrovic, J., Stojkovic, D., Reis, F. S., Barros, L., Glamoclija, J., Ciric, A., Ferreira, I. C. F. R., & Sokovic, M. (2014). Study on chemical, bioactive and food preserving properties of Laetiporus sulphureus (Bull.: Fr. Murr., Food Funct, 5(7), 1441–1451.
Reis, F. S., Barreira, J. C., Calhelha, R. C., Griensven, L. J., Ciric, A., Glamoclija, J., Sokovic, M., & Ferreira, I. C. (2014). Chemical characterization of the medicinal mushroom Phellinus linteus (Berkeley & Curtis) Teng and contribution of different fractions to its bioactivity. LWT - Food Science and Technology, 58(2), 478–485.
Reis, F. S., Barros, L., Calhelha, R. C., Ciric, A., Griensven, L. J., Sokovic, M., & Ferreira, I. C. (2013). The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties. Food and Chemical Toxicology, 62, 91–98.
Reis, F. S., Stojkovic, D., Barros, L., Glamoclija, J., Ciric, A., Sokovic, M., Martins, A., Vasconcelos, M. H., Morales, P., & Ferreira, I. C. F. R. (2014). Can Suillus granulatus (L.) Roussel be classified as a functional food? Food Funct, 5(11), 2861–2869.
Reis, F. S., Stojkovic, D., Sokovic, M., Glamoclija, J., Ciric, A., Barros, L., & Ferreira, I. C. (2012). Chemical characterization of Agaricus bohusii, antioxidant potential and antifungal preserving properties when incorporated in cream cheese. Food Research International, 48(2), 620–626.
Reverberi, M., Fabbri, A. A., Zjalic, S., Ricelli, A., Punelli, F., & Fanelli, C. (2005). Antioxidant enzymes stimulation in Aspergillus parasiticus by Lentinula edodes inhibits aflatoxin production. Applied Microbiology and Biotechnology, 69(2), 207–215.
Roberfroid, M. B. (1999). CONCEPTS IN FUNCTIONAL FOODS: A EUROPEAN PERSPECTIVE. Nutrition Today, 34(4), 162–165.
Rosa, L. H., Machado, K. M. G., Jacob, C. C., Capelari, M., Rosa, C. A., & Zani, C. L. (2003). Screening of Brazilian basidiomycetes for antimicrobial activity. Memórias Do Instituto Oswaldo Cruz, 98(7), 967–974.
Roupas, P., Keogh, J., Noakes, M., Margetts, C., & Taylor, P. (2012). The role of edible mushrooms in health: Evaluation of the evidence. Journal of Functional Foods, 4(4), 687–709.
Ruthes, A. C., Carbonero, E. R., Cordova, M. M., Baggio, C. H., Santos, A. R. S., Sassaki, G. L., Cipriani, T. R., Gorin, P. A. J., & Iacomini, M. (2013). Lactarius rufus (1→3),(1→6)-β-dglucans: Structure, antinociceptive and anti-inflammatory effects. Carbohydrate Polymers, 94(1), 129–136.
S., D., Barros, L., Calhelha, R. C., Glamoclija, J., Ciric, A., Griensven, L. J. L. D., Sokovic, M., & Ferreira, I. C. F. R. (2014). A detailed comparative study between chemical and bioactive properties of Ganoderma lucidum from different origins. International Journal of Food Sciences and Nutrition, 65(1), 42–47.
Silva, D. D., Rapior, S., Sudarman, E., Stadler, M., Xu, J., Aisyah Alias, S., & Hyde, K. D. (2013). Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry. Fungal Diversity, 62(1), 1–40.
Smiderle, F. R., Olsen, L. M., Carbonero, E. R., Baggio, C. H., Freitas, C. S., Marcon, R., Santos, A. R., Gorin, P. A., & Iacomini, M. (2008). Anti-inflammatory and analgesic properties in a rodent model of a (1→3),(1→6)-linked β-glucan isolated from Pleurotus pulmonarius. European Journal of Pharmacology, 597(1–3), 86–91.
Smiderle, F. R., Sassaki, G. L., Griensven, L. J., & Iacomini, M. (2013). Isolation and chemical characterization of a glucogalactomannan of the medicinal mushroom Cordyceps militaris. Carbohydrate Polymers, 97(1), 74–80.
Soboleva, A., Krasnopol’Skaia, L., Fedorova, G., & Katrukha, G. (2006). Antibiotic properties of the strains of the basidiomycete Lentinus edodes (Berk.) sing. Antibiotiki Khimioterapiya, 51, 3–8.
Sokovic, M., Ciric, A., Glamoclija, J., & Stojkovic, D. (2017). The Bioactive Properties of Mushrooms. In Wild Plants, Mushrooms and Nuts (pp. 83–122).
Stojkovic, D., Reis, F. S., Barros, L., Glamoclija, J., Ciric, A., Griensven, L. J., Sokovic, M., & Ferreira, I. C. (2013). Nutrients and non-nutrients composition and bioactivity of wild and cultivated Coprinus comatus (O.F.Müll. Pers., Food and Chemical Toxicology, 59, 289–296.
Stojkovic, D., Reis, F. S., Ferreira, I. C., Barros, L., Glamoclija, J., Ciric, A., Nikolic, M., Stevic, T., Giveli, A., & Sokovic, M. (2013). Tirmania pinoyi: Chemical composition, in vitro antioxidant and antibacterial activities and in situ control of Staphylococcus aureus in chicken soup. Food Research International, 53(1), 56–62.
Stojkovic, D., Reis, F. S., Glamoclija, J., Ciric, A., Barros, L., Griensven, L. J. L. D., Ferreira, I. C. F. R., & Sokovic, M. (2014). Cultivated strains of Agaricus bisporus and A. brasiliensis: chemical characterization and evaluation of antioxidant and antimicrobial properties for the final healthy product – natural preservatives in yoghurt. Food & Function, 5(7), 1602.
Stojkovic, D. S., Kovacevic-Grujicic, N., Reis, F. S., Davidovic, S., Barros, L., Popovic, J., Petrovic, I., Pavic, A., Glamoclija, J., Ciric, A., Stevanovic, M., Ferreira, I. C., & Sokovic, M. (2017). Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract. LWT - Food Science and Technology, 79, 454–462.
Valverde, M., Hernandez-Perez, T., & Paredes-Lopez, O. (2015). Edible Mushrooms: Improving Human Health and Promoting Quality Life. International Journal of Microbiology.
Venturini, N., Muniz, P., Bicego, M. C., Martins, C. C., & Tommasi, L. R. (2008). Petroleum contamination impact on macrobenthic communities under the influence of an oil refinery: Integrating chemical and biological multivariate data. Estuarine, Coastal and Shelf Science, 78(3), 457–467.
Wang, M., Meng, X. Y., Yang, R. L., Qin, T., Wang, X. Y., Zhang, K. Y., Fei, C. Z., Li, Y., Hu, Y., & Xue, F. Q. (2012). Cordyceps militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice. Carbohydrate Polymers, 89(2), 461–466.
Wasser, S. (2014). Medicinal mushroom science: Current perspectives, advances, evidences, and challenges. Biomedical Journal, 37(6), 345.
Wasser, S. P. (2010). Medicinal Mushroom Science: History, Current Status, Future Trends, and Unsolved Problems. International Journal of Medicinal Mushrooms, 12(1), 1–16.
Wasser, S. P. (2011). Current findings, future trends, and unsolved problems in studies of medicinal mushrooms. Applied Microbiology and Biotechnology, 89(5), 1323–1332.
Whittaker, R. (1969). New concepts of kingdoms of organisms. Science, 163, 150–160.
W.H.O. (2001). World Health Organization | Global Strategy for Containment of Antimicrobial Resistance.
Zahid, S., Udenigwe, C. C., Ata, A., Eze, M. O., Segstro, E. P., & Holloway, P. (2006). New bioactive natural products from Coprinus micaceus. Natural Product Research, 20(14), 1283–1289.
Zain, M. E. (2011). Impact of mycotoxins on humans and animals. Journal of Saudi Chemical Society, 15(2), 129–144.
Zjalic, S., Reverberi, M., Ricelli, A., Mariogranito, V., Fanelli, C., & Adelefabbri, A. (2006). Trametes versicolor: A possible tool for aflatoxin control. International Journal of Food Microbiology, 107(3), 243–249.
Citation
Copyright
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
