The roots of yellow gentian, Gentiana lutea L. (Gentianaceae) are used in traditional medicine for the treatment of gastrointestinal disorders, with the literature data indicate a local gastric effect of gentian root extract (GRE) and support the use of the solid pharmaceutical forms. Gentiopicroside, as a dominant secoiridoid in the GRE, has a sho...

By Jelena Mudrić, Mirjana Pajić, Dubravka Bigović, Jelena Đuriš

This study aimed to assess the antineurodegenerative and antioxidant activity of Helichrysum plicatum flower extract, as well as to identify extract ingredients with acceptable pharmacokinetic parameters such as gastrointestinal absorption, blood-brain barrier permeation, and P-glycoprotein-mediated effusion for optimal therapeutic brain exposure. ...

By Miloš Jovanović, Zorica Drinić, Dubravka Bigović, Ana Alimpić-Aradski, Sonja Duletić-Laušević, Katarina Šavikin

Fruticin (amorphin) is a constituent of the fruit of the false indigo-bush (Amorpha fruticosa L.), which belongs to the class of rotenoid glycosides, and shows several interesting pharmacological activities. The aim of this study was to isolate and chemically characterize this natural product, as well as to determine the optimal period of the year ...

By Stevan Samardžić, Aleksandra Tucović, Danilo Stojanović, Zoran Maksimović

Staphylococcus aureus is a human pathogen that causes serious infections with high mortality rates. The antimicrobial activities of eight phenolic compounds (caffeic acid, chlorogenic acid, ferulic acid, morin, quercetin, isoquercitrin, rutin and hesperidin) were evaluated against planktonic and biofilm forming Staphylococcus aureus cells. Their ab...

By Marina Kostić, Marija Ivanov, Dejan Stojković, Ana Ćirić, Marina Soković

This study represents a continuation of exploring of the biological activities of the Artemisia santonicum essential oil. The previous investigation was focused on the antibacterial, antibiofilm, and antiquorum activities of A. santonicum essential oil and isogeranic acid as the main antibacterial constituent. The present study describes their anti...

By Jovana Stankov-Jovanović, Miroslav Novaković, Miroslav Novaković, Vele Tešević, Gordana Zdunić, Zora Dajić Stevanović, Dejan Gođevac

Lady’s mantle (Alchemilla vulgaris L. syn. Alchemilla xanthochlora Rothm., Rosaceae) has been commonly used in folk medicine to heal inflammations in the mouth, bleeding of the nose, furuncules, gynaecological (menorrhagia and dysmenorrhoea), and gastrointestinal disorders. Although therapeutic indications for Lady’s mantle are non-specific diarrho...

By Vanja Tadić, Nemanja Krgović, Ana Žugić

The aim of this study was to characterize volatile and non-volatile compounds of rosemary from the North Adriatic region and to determine its antiproliferative activity, alone or in combination with radiomimetic bleomycin (BLM) on three malignant and one non-transformed human cell line. Chemical analysis of the volatile compounds revealed the prese...

By Jasminka Mrđanović, Višnja Bogdanović, Biljana Kiprovski, Đorđe Malenčić, Maja Mikulič-Petkovšek, Ivan Milovanović, Aleksandra Mišan

The impact of ploidy level on both the regenerative potential under in vitro conditions and the production of major bioactive specialized metabolites, such are iridoids and xanthones, was examined in Centaurium erythraea Rafn. Shoot regeneration frequency was genotype dependent, but not affected by explant ploidy level. In most cases, the regenerat...

By Biljana Filipović, Branislav Šiler, Jasmina Nestorović-Živković, Tijana Banjanac, Marijana Skorić, Jelena Božunović, Danijela Mišić

<i>Ocimum basilicum<i> (sweet basil) and <i>Laurus nobilis</i> (bay leaves or laurel) have been used in traditional medicine for centuries, and also extensively employed as spices for adding aroma and flavor to various food products. <i>Citrus reticulata</i>  (mandarin) is mainly used in food industry for ju...

By Sonja Duletić-Laušević, Mariana Oalđe, Ana Alimpić-Aradski

Herbal products have gained popularity, and they are often perceived as safe. The roles of the pharmacists and physicians are essential in the proper usage of those products. This study aimed to investigate the students of Faculty of Medicine in Niš about the use of herbal preparations and the differences between medicine, pharmacy and denti...

By Emilija Kostić, Milica MIlutinović, Milica Kostić, Jasmina Petrović, Bojana Miladinović, Suzana Branković, Maja Vujović, Dušanka Kitić