Extraction of sweet wormwood (Artemisia annua L.) by supercritical carbon dioxide
In this study, supercritical carbon dioxide was applied for the extraction of Artemisia annua L. Moreover, the impact of different parameters of supercritical extraction on total yield was investigated and the obtained yields were compared to the ones obtained by conventional procedures, hydrodistillation and Soxhlet extraction. Supercritical fluid...
By Senka Vidović, Siniša Simić, Aleksandra Gavarić, MIlica Aćimović, Jelena Vladić
Ethnomedicinal application of species from genus Thymus in the Pirot County (Southeastern Serbia)
The species from genus Thymus are polymorphous plants from the family Lamiaceae, spread in Serbia in many species, subspecies, varieties, and forms. The aerial parts of species from genus Thymus have a long tradition of being used worldwide. The subject of this study was the research of ethnomedicinal application of thyme in Pirot County (Southeast...
By Marija Marković, Dejan Pljevljakušić, Biljana Nikolić, Ljubinko Rakonjac, Vesna Stankov-Jovanović
GC/MS chemical analysis of lavandin (Lavandula x intermedia) hydrolat: successive extraction fractions
Hydrolats are valuable co-products of the essential oil distillation process, whose volatile compounds can be quantified by various methods. In this paper, we have tried to estimate the liquid-liquid extraction cycle number threshold for volatile compounds quantification of lavandin (Lavandula x intermedia) hydrolat. For this purpose, ten consecuti...
By Dejan Pljevljakušić, Zorica Drinić
Development of gastroretentive floating granules with gentian root extract by hot-melt granulation
The roots of yellow gentian, Gentiana lutea L. (Gentianaceae) are used in traditional medicine for the treatment of gastrointestinal disorders, with the literature data indicate a local gastric effect of gentian root extract (GRE) and support the use of the solid pharmaceutical forms. Gentiopicroside, as a dominant secoiridoid in the GRE, has a sho...
By Jelena Mudrić, Mirjana Pajić, Dubravka Bigović, Jelena Đuriš
In vitro and in silico prediction of antineurodegenerative properties of Helichrysum plicatum flower extract
This study aimed to assess the antineurodegenerative and antioxidant activity of Helichrysum plicatum flower extract, as well as to identify extract ingredients with acceptable pharmacokinetic parameters such as gastrointestinal absorption, blood-brain barrier permeation, and P-glycoprotein-mediated effusion for optimal therapeutic brain exposure. ...
By Miloš Jovanović, Zorica Drinić, Dubravka Bigović, Ana Alimpić-Aradski, Sonja Duletić-Laušević, Katarina Šavikin
Isolation and seasonal variation of fruticin in fruits of false indigo-bush (Amorpha fruticosa L. Fabaceae) from Serbia
Fruticin (amorphin) is a constituent of the fruit of the false indigo-bush (Amorpha fruticosa L.), which belongs to the class of rotenoid glycosides, and shows several interesting pharmacological activities. The aim of this study was to isolate and chemically characterize this natural product, as well as to determine the optimal period of the year ...
By Stevan Samardžić, Aleksandra Tucović, Danilo Stojanović, Zoran Maksimović
Cytotoxic activity of supercritical CO2 extract of old man’s beard in L929 fibrosarcoma cell line
Usnea barbata (old man’s beard) is one of the most investigated lichens which biological properties (such as antimicrobial, anti-inflammatory and cytotoxic activities) have been proven in several scientific studies. Stated properties of old man’s beard have been attributed mainly to its major secondary metabolite - a dibenzofuran deriva...
By Ana Žugić, Aleksandra Isaković, Ivica Jeremić, Vanja Tadić
Variation of parthenolide and phenolic compounds content in different parts of Tanacetum parthenium (L.) Schulz Bip., Asteraceae during 18 months storage
Tanacetum parthenium (L.) Schulz Bip., Asteraceae (feverfew), being a medicinal plant with a long tradition in European folk medicine, has been used to treat headache, fever, rheumatism, asthma, stomach pains, and other conditions related to inflammation. Although feverfew is often used for migraine headaches, numerous literature data stated the in...
By Vladan Tadić, Jelena Živković, Dubravka Bigović, Ana Žugić
Investigation of stability of cold pressed linseed (Linum usitatissimum L.) oil
The stability of linseed (Linum usitatissimum) oil has been investigated through the exposition of two different samples, linseed oil without antioxidant and linseed oil with roesemary (Rosmarinus officinalis) extract, to ambient temperature conditions (25 °C) and refrigerator temperature conditions (4 °C). The oxidation degree of linseed oi...
By Zorica Drinić, Jelena Mudrić, Gordana Zdunić, Dubravka Bigović, Katarina Šavikin
Novel insights to the anti-proliferative activity of rosemary (Rosmarinus officinalis L.) co-treatment
The aim of this study was to characterize volatile and non-volatile compounds of rosemary from the North Adriatic region and to determine its antiproliferative activity, alone or in combination with radiomimetic bleomycin (BLM) on three malignant and one non-transformed human cell line. Chemical analysis of the volatile compounds revealed the prese...
By Jasminka Mrđanović, Višnja Bogdanović, Biljana Kiprovski, Đorđe Malenčić, Maja Mikulič-Petkovšek, Ivan Milovanović, Aleksandra Mišan